Interventional
Sleep
Medicine
The sleeping state is an ideal time to administer therapeutic agents.
With the body quiescent, a variety of sensors can readily detect triggering events that signal dosing time points. The sleep state also allows autonomous and rapid administration.
“The next revolution in sleep medicine will come when we stop treating sleep as a passive state and begin prescribing it as an active biological process that can be measured, shaped, and optimized.”
— Dr. Matthew Walker
PATENT CLAIMS
Problem: Humans sleep for 20-30% of their lifetimes. Yet, the practice of sleep medicine is largely passive—monitoring for issues during sleep that can then be treated while awake. This paradigm divorces clear advantages of cause-and-effect timing and ignores characteristics of sleep that can simplify treatment.
Solution: Utilize sleep for both monitoring AND treatment. Sensor arrays of various types can be used to detect individual signals or collections of signals (i.e. “triggers”) in real time to actuate the delivery of key therapeutic compounds via rapid methods. This enables precise timing in enacting physiological state change.
More Depth
The pervasive use of personal biometric devices (e.g. FitBits, iPhones) and the burgeoning internet of things is creating a surfeit of biometric data that can be utilized to hitch our electronic worlds and our biochemical worlds in a more steadfast union across various states of consciousness. High bitrate feedback and feedforward between what is happening in the real world (or virtual worlds) and what a biological system feels, thinks, and perceives will enable more evolutionarily adaptive responses to those biological systems in whatever environment they find themselves.
Value
KEY
Future at Present
Stands-up the paradigm of active sleep medicine by utilizing existing sleep monitoring tools and infrastructure.
Bioavailability
Utilizes routes of administration that achieve rapid onset and efficient passage of the blood-brain barrier.
Less Partial
Expands treatment attention beyond the waking state.
Simplicity
Allows for the detection of key events during a state of sleep AND followed by deployment of a pharmacological intervention.
Active
Helps the field of Sleep Medicine turn the corner from passive observation to personalized intervention.
Pharmacological Breadth
Enables use for both therapeutic and wellness applications.
Who Should License
U.S. Patent 11,670,410 helps to usher in the future of active and interventional sleep medicine.
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Entraining next generation BCI devices will require a focus beyond the motor and sensory cortices during the waking state.
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Current sleep medicine centers are heavy with instrumentation, but often light on patient enthusiasm and bookings. By making sessions more tangibly therapeutic, the value of sleep medicine will become more self-evident.
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Wellness can be paired with a rejuvenating nap. Medical spa users are already open to the potential of interventions paired with relaxation—why not expand the power of their options.